Gombe Stream National Park, located on the western border of Tanzania, can be easily reached by boat from Kigoma town, which is 16 km to the south. Despite its small size of only 52 sq km, Gombe Stream is one of Tanzania's smallest National Parks. It consists of a narrow strip of mountainous terrain, bordered to the east by the crest of the Great Rift Valley escarpment and to the west by Lake Tanganyika, which is the world's longest and second deepest at 1400 meters deep.

Similar to its neighboring park, Mahale Mountains, Gombe Stream does not have any roads, allowing visitors to explore nature on foot while accompanied by a park guide. The park's vegetation varies from evergreen forests with tall trees to open woodlands and grasslands. The most notable feature of the park is its chimpanzees, which have gained fame through the research conducted by Jane Goodall. Chimpanzees are classified as an endangered species and serve as the primary attraction for visitors to Gombe.

Gombe Stream is home to other forest-dwelling mammals, predominantly primates such as baboons, blue monkeys, vervet monkeys, red-tailed monkeys, and red colobus monkeys. The park also boasts a diverse bird population, with over 200 species of birds residing within its boundaries.